Recent work

Dougherty ML*, Nuttle X*, Penn O, Nelson BJ, Huddleston J, Baker C, Harshman L, Duyzend MH, Ventura M, Antonacci F, Sandstrom R, Dennis MY, Eichler EE. The birth of a human-specific neural gene by incomplete duplication and gene fusion. Genome biology. 2017; 18(1):49.

Dennis MY, Harshman L, Nelson BJ, Penn O, Cantsilieris S, Huddleston J, Antonacci F, Penewit K, Denman L, Raja A, Baker C, Mark K, Malig M, Janke N, Espinoza C, Stessman HA, Nuttle X, Hoekzema K, Graves TA, Wilson RK, Eichler EE. The evolution and population diversity of human-specific segmental duplications. Nat Ecol Evol. 2017 Mar. (Supplementary Information) (Supplementary Tables) (Supplementary Data)

Dennis MY and Eichler EE. Human adaptation and evolution by segmental duplication. Curr Opin Genet Dev. 2016 Dec; 41:44–52

*These authors contributed equally to this work; authors in bold represent Dennis lab members


Mazina V, Gerdts J, Ankenman K, Ward T, Dennis MY, Girirajan S, Eichler EE, and Bernier R. Epigenetics of autism-related impairment: Copy number variation and maternal infection. JDBP. 2015 Feb-Mar;36(2):61-7.

Chaisson MJ, Huddleston J, Dennis MY, Sudmant PH, Malig M, Hormozdiari F, Antonacci F, Surti U, Sandstrom R, Boitano M, Landolin J, Stamatoyannopoulos JA, Hunkapiller MW, Korlach J, Eichler EE. Resolving the complexity of the human genome using single-molecule sequencing. Nature. 2015 Jan 29;517(7536):608-11.

Antonacci F*, Dennis MY*, Huddleston J, Sudmant PH, Meltz Steinberg K, Graves TA, Vives L, Malig M, Denman L, Baker C, Amemiya CT, Stuart A, Tang J, Muson B, Rosenfeld JA, Shaffer LG, Wilson RK, and Eichler EE (2014). Palindromic GOLGA8 core duplicons promote 15q13.3 microdeletion and evolutionary instability. Nat Genet. Dec;46(12):1293-302. 

Key FM, Peter B, Dennis MY, Huerta-Sanchez E, Tang W, Nielsen R, Prokunina-Olsson L, and Andres AM (2014). Selection on a variant associated with improved viral clearance induced local, adaptive pseudogenization of interferon lambda 4 (IFNL4). PLOS Genet 10(10):e1004681.

Huddleston JH, Ranade S, Malig M, Antonacci F, Chaisson M, Hon L, Sudmant PH, Graves TA, Alkan C, Dennis MY, Wilson RK, Turner SW, Korlach J, and Eichler EE (2014). Reconstructing complex regions of genomes using long-read sequencing technology. Genome Res 24(4):688-96.

Girirajan S*, Dennis MY*, Baker C, Malig M, Coe BP, Campbell CD, Mark K, Vu TH, Alkan C, Cheng Z, Biesecker LG, Bernier R, and Eichler EE (2013). Refinement and discovery of new hotspots of copy number variation associated with autism spectrum disorder. AJHG 92(2):221-37.

Dennis MY*, Nuttle X*, Sudmant PH, Antonacci F, Graves TA, Nefedov M, Rosenfeld JA, Sajjadian S, Malig M, Kotkiewicz H, Curry CJ, Shafer S, Shaffer LG, de Jong PJ, Wilson RK, and Eichler EE (2012). Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication. Cell 149(4):912-22.

Karakoc E, Alkan C, O'Roak BJ, Dennis MY, Vives L, Mark K, Rieder MJ, Nickerson DA, and Eichler EE (2011). Detection of structural variants and indels within exome data. Nat Methods 9(2):176-8.

*These authors contributed equally to this work

2010 and before

Antonellis A*, Dennis MY*, Burzynski G, Huynh J, Maduro V, Khajavi M, Szigeti K, Mukkamala S, Bessling SL, NISC Comparative Sequencing Program, McCallion AS, Pavan WJ, Lupski JR, and Green ED (2010). A rare myelin protein zero (MPZ) variant alters enhancer activity in vitro and in vivo. PLOS One 5(12):e14346.

Andres AM*, Dennis MY*, Kretzschmar W, Cannons JL, Lee-Lin S, Hurle B, NISC Comparative Sequencing Program, Schwartzberg PL, Williamson S, Bustamante CD, Nielsen R, Clark AG, and Green ED (2010). Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. PLOS Genet 6(10): e1001157.

Dennis MY, Paracchini S, Scerri TS, Prokunina-Olsson L, Knight JC, Wade-Martins R, Coggill P, Beck S, Green ED, and Monaco AP (2009). A common variant associated with dyslexia reduces expression of the KIAA0319 gene. PLOS Genet 5(3): e1000436.

Harold D*, Paracchini S*, Scerri T, Dennis M, Cope N, Hill G, Moskvina V, Walter J, Richardson AJ, Owen MJ, Stein JF, Green ED, O'Donovan MC, Williams J, Monaco AP (2006). Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia. Mol Psychiatry 11, 1085-1091, 1061.

*These authors contributed equally to this work